This Step-Up Series volume is a high-yield, systems-based, outline-format review of commonly tested USMLE Step 2 material, including internal medicine subspecialties, required clerkship specialties, and important topics in medical practice. The user-friendly format, with numerous tables, illustrations, and flow charts, allows quick review of a vast body of facts. “Quick Hit” marginalia highlight facts likely to be tested. “Next Step” marginalia indicate what the clinician must do next after making a diagnosis. A full-color section illustrates classic presentations of dermatologic and other disorders. This edition includes additional Quick Hits, mnemonics, new illustrations, expanded coverage of ARDS, a new table on breast malignancy variants, and updated vaccination schedules.